MEPS-BBB

Provides perfusion flow to vascular endothelium

Tri-cultured BBB cells

3D astrocyte culture with polarized end-feet processing

Study the dynamic response of human cells to various drug administration conditions (time and dosage)

Evaluate the permeability and mechanisms of the drug through BBB

Evaluate the targeting efficacy for brain cells like glia

Human Blood-Brain Barrier

Blood flow-induced shear stress on endothelium

Interactions and communications of BBB cells (co-cultured)

Astrocytic end-feet processing (AQP4,…)

3D microenvironment (ECM: colagen4, laminin, …)

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More physiologically accurate BBB reconstitution

Mimicking neuroinflammation with astrocytes

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